This protein has three key structural domains: an N-terminal importin β-binding (IBB) domain, armadillo (Arm) repeats that function as internal cargo cNLS- ...
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Here we show by site-directed mutagenesis that the very C-terminal arm repeats 8 and 9 of importin alpha5 form a unique binding site for STAT1 homodimers and ...
May 22, 2021 · All importin α proteins contain one importin β1 binding (IBB) domain at the N-terminal end, and the rest of the sequence contains 10 Armadillo ( ...
Jan 10, 2022 · The classical nuclear import pathway is mediated by specific interactions between proteins from the karyopherin family and cargo proteins ...
The arm repeats are variable within one protein, but they are remarkably conserved in sequence and order when homologous proteins from yeast to humans are ...
Jun 11, 2016 · Importin α performs the indispensable role of ferrying proteins from the cytoplasm into the nucleus with a transport carrier, importin β1.
Sep 12, 2018 · Because these ARM repeats provide a critical point of difference between the binding of importin α isoforms, we investigated why the W NLS ...
The ARM repeats of free importin α in the cytoplasm bind the NLS of nucleus targeted proteins while the IBB domain simultaneously joins to an importin β protein ...
Importin-alpha contains several armadillo (ARM) repeats, which produce a curving structure with two NLS-binding sites, a major one close to the N terminus and a ...
One strategy to evade host innate immune responses involves blocking the nuclear import of host antiviral transcription factors. By binding IMPA proteins, these ...